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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often characterized by a focus on the practical aspects of the research design, like recruitment and consent, adherence, and the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and participants from various geographical areas. This type of heterogeneity is required for practical trials to be valid and also helps reduce bias in the results. A high degree of heterogeneity, however can result in problems with the trial design.

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Pragmatic Play is renowned for its top-notch games, and for providing a superior user experience. Its software is designed to work with mobile devices and supports different languages. Despite its relatively young age it has already established itself as a premier casino gaming platform. Wolves is one of the most recent releases, a 5-reel slot machine with a hefty RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

The aim of pragmatic trials is to simulate real-life situations and achieve maximum credibility externally. They are usually requested by practitioners and policy makers to inform their decision making. They can be used to determine the cause-effect relationship of an intervention and its effects. However, they should not be used as a substitute for the use of explanation trials.

The idea of pragmatism is controversial and there are concerns about whether pragmatic trials can be used to replace explanation tests or if they should be an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, 프라그마틱 슬롯 팁 which validate the validity of a clinical or physiological hypothesis, and pragmatic trials, which inform policy and practice decisions. They also proposed a framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the elements of a pragmatic study, including recruitment, design and delivery of the intervention, and monitoring.

The number of pragmatic trials is increasing. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This is a sign that the health science community is becoming more acquaint to the issue of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary-care settings.